This study proposes the application of the methodological framework for functional analysis of technological innovation systems in the context of the implementation of a regional smart specialization strategy. The case focuses on the solar energy industry in the Arequipa region – Peru. For this purpose, interviews, surveys and workshops were conducted with more than 70 stakeholders. The results allowed for the formulation of specific initiatives based on the identification of certain blocking mechanisms. The proposed approach can contribute to the development of innovation policies with regional scope, especially in territories with low scientific-technological infrastructure.