In spite of the fact that we are immersed in a global economy,in many aspects innovation is mainly a regional phenomenon,in which services,(ne- glected until now)and in particular those called knowledge intensive services (KIS), acquire a central role,thanks to their capacity to transmit knowledge,especially of a tacit type.The aim of this paper is to carry out an initial empirical analysis of the ef- fects associated with the location of KIS,using 107 European regions.The results ob- tained support the hypothesis that KIS exert a positive impact on regional innovative performance,an impact that could spill over into the neighbouring regions.