The use of location quotients for the estimation of regional input‑output tables has been found to be a useful and efficient tool to estimate intra-regional production multipliers. Building on this tool, more complex procedures have been developed that simultaneously estimate inter-regional coefficients. This paper assesses the capacity of this extended methodology (called the Jahn methodology) to obtain both intra-regional and inter-regional multipliers for the Spanish case, using the Input-Output Table (IOT) of Spain 2015 to estimate those corresponding to the Spanish regions of Andalusia, the Basque Country and Navarra for the same year and whose results are available via survey. In order to contrast their reliability, efficiency and accuracy, the results obtained with this procedure are then compared with other methodologies widely used for their recognised efficiency, the GRAS and Gravity-RAS methodologies.