This paper provides a revision on the growing interdependencies that today we can find among the works that address the business dynamics and spatial economics. In recent years, an increasing attention to knowledge as competitive resource of businesses and territories, the presence of increasing returns in growth trajectories and the role of major metropolitan areas, among others, has facilitated the study of the dynamics entrepreneurship and innovation from a territorial approach. The articles compiled in this special issue were presented on Symposium on Business Dynamics and Innovation: The effects of agglomeration economies, organized by the Reference Network of Catalonia Applied Economics and Regional Research magazine.