Portugal’s globalization and integration had positive repercussions at the economic and social development level, but simultaneously it evidenced regional asymmetries, demanding new explanatory models to lessen existent disparities. Recent paradigms value the endogenous characteristics of the territory that appear decisive of the country’s development, including the idea that regions and local agents should identify new kinds of production organization and relationships, thus enhancing clusters. Given that, in the Beira Interior Norte, craftwork activities assume a relative economic and social importance, the purpose of the present paper is to verify whether this sector acquires the cluster classification in the region and continuously characterized this classification while potential cluster promote and develop economic and social factors.